| 陈伟,梁永强,汤献忠,等.早期应用谷氨酰胺治疗对老年结直肠癌病人术后胰岛素抵抗和炎性因子的影响[J].安徽医药,2022,26(2):409-412. |
| 早期应用谷氨酰胺治疗对老年结直肠癌病人术后胰岛素抵抗和炎性因子的影响 |
| Effect of early glutamine treatment on postoperative insulin resistance and inflammatory factors in elderly patients with colorectal cancer |
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| DOI：10.3969/j.issn.1009-6469.2022.02.048 |
| 中文关键词: 谷氨酰胺 手术后期间 老年人 结直肠癌 营养 胰岛素抵抗 炎性因子 |
| 英文关键词: Glutamine Postoperative period Elderly Colorectal cancer Nutrition Insulin resistance Inflammatory fac. tors |
| 基金项目:东莞市科技发展项目( 201650715001399) |
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| 中文摘要: |
| 目的探讨早期应用谷氨酰胺治疗对老年结直肠癌病人营养指标、术后胰岛素抵抗( IR)、炎性因子和并发症的影响。方法收集 2018年 1月至 2019年 12月东莞市人民医院 90例老年结直肠癌病人作为观察对象，采用随机数字表法分为对照组和观察组，每组各 45例。所有病人均接受手术治疗。术后，对照组给予常规早期肠内营养治疗，观察组在对照组基础上早期给予谷氨酰胺治疗。比较两组病人手术前后营养指标、 IR指标、炎性因子水平及术后并发症发生率。结果术后 1周，观察组病人总蛋白［( 72.70±8.53)g/L比( 68.29±8.24)g/L］、前白蛋白［( 214.79±23.06)mg/L比( 182.51±29.58)mg/L］和白蛋白［( 38.19± |
| 英文摘要: |
| Objective To investigate the effect of early glutamine treatment on nutrition indices, postoperative insulin resistance(IR), inflammatory factors and complications in elderly patients with colorectal cancer.Methods A total of 90 elderly patients withcolorectal cancer in Dongguan People's Hospital from January 2018 to December 2019 were collected as observational objects, andwere divided into control group and observation group by random number table method, with 45 cases in each group. All patients re.ceived operation therapy. After operation, the control group was given conventional early enteral nutrition treatment, and the observa.tion group was given early glutamine treatment on the basis of the control group. Levels of nutrition indices, IR indices, inflammatoryfactors before and after operation and incidence of postoperative complications were compared.Results One week after operation, nu. trition indices of total protein [(72.70±8.53)g/L vs. (68.29±8.24)g/L], prealbumin [(214.79±23.06)mg/L vs. (182.51±29.58)mg/L] and al. bumin [(38.19±6.72)g/L vs. (34.65±6.20)g/L] in the observation group were higher than those in the control group (all P<0.05). Threedays after operation, in comparison with the control group, the observation group had lower levels of IR indices of fasting blood glucose(FBG) [(6.47±1.02)mmol/L vs. (7.01±1.22)mmol/L], fasting insulin (FINS) [(10.71±2.04)μU/mL vs. (14.23±2.46)μU/mL], HOMA-IR [(3.26±0.75) vs. (1.52±0.23)] and lower levels of inflammatory factors of tumor necrosis factor α (TNF-α) [(51.08±4.36)ng/L vs. (71.49± 5.20)ng/L], interleukin 6 (IL-6) [(17.42±3.95)ng/L vs. (20.27±4.51)ng/L], C-reactive protein (CRP) [(9.81±2.20)mg/L vs. (13.53±3.02) mg/L] with all statistical differences (all P<0.05).Conclusion For elderly patients with colorectal cancer who receives operation thera.py, early glutamine treatment can not only improve nutritional status, but also effectively alleviate postoperative IR and inflammatory re.action with reduced postoperative complications. |
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