| 余家快,王婷,张玉,等.抑郁症病人睡眠结构特征与前瞻性记忆的相关性研究[J].安徽医药,2022,26(12):2489-2493. |
| 抑郁症病人睡眠结构特征与前瞻性记忆的相关性研究 |
| The correlation between sleep structure characteristics and prospective memory in patients with depression |
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| DOI：10.3969/j.issn.1009-6469.2022.12.034 |
| 中文关键词: 抑郁症 睡眠结构 前瞻性记忆 因果律 |
| 英文关键词: Depression Sleep structure Prospective memory Causality |
| 基金项目:合肥市卫生计生应用医学研究项目( hwk2018yb001) |
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| 中文摘要: |
| 目的探讨抑郁症病人睡眠结构特征及其与前瞻性记忆的相关性。方法选取 2017年 1月至 2020年 1月安徽省精神卫生中心 113例住院抑郁症病人作为抑郁组，同期该中心公开招募 47例健康者作为对照组，两组对象均行多导睡眠监测，评估汉密尔顿抑郁量表( HAMD)、汉密尔顿焦虑量表( HAMA)、基于事件的前瞻性记忆( EBPM)和基于时间的前瞻性记忆( TBPM)，分析抑郁症病人睡眠结构与 EBPM和 TBPM的关系。结果相比于对照组，抑郁组快速眼动睡眠( REM)潜伏期( 235.52±83.65)min和卧床时间 507.00(49.25)min较对照组 REM潜伏期( 137.78±56.23)min和卧床时间 483.80(54.50)min长( P<0.05)；抑郁组 EBPM评分 2.00(5.00)分和 TBPM评分 2.00(4.00)分较对照组的 EBPM 6.00(5.00)分和 TBPM 5.00(5.00)分少( P<0.05)。相关性分析显示，抑郁组 N2潜伏期与 TBPM呈正相关［ β=0.041，95%CI:(0.008，0.074)］，REM持续时间与 TBPM呈正相关［ β=0.024，95%CI:(0.010，0.039)］。模型加入性别、年龄、文化、体质量指数( BMI)、 HAMD、HAMA、病程等混杂因素后，多因素线性回归分析结果显示，抑郁组 REM持续时间仍与 TBPM呈正相关［ β=0.017，95%CI:(0.003，0.031)］；而 N2潜伏期与 TBPM的关联差异无统计学意义( P>0.05)。结论抑郁症病人存在睡眠结构异常和前瞻性记忆损害， TBPM与 REM持续时间呈正相关，且这种关联不受病人性别、年龄、文化、体质量指数、抑郁程度、焦虑程度和病程等的影响。 |
| 英文摘要: |
| Objective To explore the structural sleep characteristics of depressed patients and their correlation with prospective memory.Methods A total of 113 hospitalized depressed patients from January 2017 to January 2020 at Anhui Provincial MentalHealth Center were selected as the depression group, and 47 healthy individuals were openly recruited as the control group during thesame period. The subjects in both groups underwent polysomnography to assess the Hamilton Depression Scale (HAMD), HamiltonAnxiety Inventory (HAMA), event-based prospective memory (EBPM), and time-based prospective memory (TBPM), and the relation.ship between sleep structure and EBPM and TBPM in depressed patients was analyzed.Results The rapid eye movement (REM) sleepincubation period [(235.52±83.65) min] and bedtime (TIB) [507.00 (49.25) min] were longer in the depressed group than in the controlgroup for the REM sleep incubation period [(137.78±56.23) min] and TIB [483.80 (54.50) min] (P<0.05). The EBPM score [2.00 (5.00)points] and TBPM score [2.00 (4.00) points] in the depressed group were lower than those in the control group (EBPM [6.00 (5.00)points] and TBPM [5.00 (5.00) points]) (P<0.05). Correlation analysis showed that the N2 incubation period in the depression group was positively correlated with TBPM [β=0.041, 95%CI: (0.008, 0.074)] and REM duration was positively correlated with TBPM [β=0.024, 95%CI: (0.010, 0.039)]. After adding confounders such as sex, age, culture, body mass index (BMI), HAMD, HAMA, and duration of ill.ness to the model, multivariate linear regression analysis showed that REM duration remained positively correlated with TBPM in thedepression group [β=0.017, 95%CI: (0.003, 0.031)], while the difference between the association of N2 latency and TBPM was not sta. tistically significant (P>0.05).Conclusions Depressed patients had abnormal sleep structure and prospective memory impairment, and TBPM was positively associated with REM duration. This association was not affected by patient gender, age, culture, body mass in.dex, depression level, anxiety level, or disease duration. |
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