| 赵晓慧,李爽.循环肿瘤细胞、微小 RNA-196a、肿瘤特异性生长因子在宫颈癌中的表达及与临床病理特征和预后的关系[J].安徽医药,2023,27(4):814-818. |
| 循环肿瘤细胞、微小 RNA-196a、肿瘤特异性生长因子在宫颈癌中的表达及与临床病理特征和预后的关系 |
| Expression of CTC-s, miR-196a and TSGF in cervical cancer and their relationship with clinicopathological features and prognosis of patients |
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| DOI：10.3969/j.issn.1009-6469.2023.04.042 |
| 中文关键词: 宫颈肿瘤 循环肿瘤细胞 微小 RNA-196a 肿瘤特异性生长因子 临床病理特征 预后 |
| 英文关键词: Uterine cervical neoplasms CTC-s miR-196a Tumor specific growth factor Clinicopathological features Prognosis |
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| 中文摘要: |
| 目的分析循环肿瘤细胞( CTC-s)、微小 RNA-196a(miR-196a)、肿瘤特异性生长因子( TSGF)在宫颈癌病人中的表达，并探讨其与临床病理特征和预后的关系。方法回顾性收集 2016年 1月至 2017年 3月北京中医医院顺义医院收治的 116例宫颈癌病人作为癌症组，同期收集该院体检中心 100例健康女性作为对照组。检测两组研究对象的 CTC-s、miR-196a、 TSGF水平，并分析其与病人临床病理特征和预后的关系。结果癌症组 CTC-s(5.92±1.32)U/mL、miR-196a(5.82±1.44)、 TSGF(109.65±27.68)U/mL明显高于对照组的( 0.55±0.14)U/mL、1.05±0.23、(30.54±8.11)U/mL，差异有统计学意义( P<0.05)。根据临床病理特征分组结果显示国际妇产科协会( FIGO)分期 ≥ⅡB期、低分化、浸润深度 >1/2肌层、有淋巴结转移的宫颈癌病人 CTC-s分别为( 6.83±1.49)U/mL、(6.88±1.60)U/mL、(6.97±1.50)U/mL、(7.06±1.54)U/mL，miR-196a分别为 7.01±1.57、6.82±1.48、7.00±1.57、7.11±1.61，TSGF分别为( 125.48±30.02)U/mL、(128.03±33.02)U/mL、(127.87±34.01)U/mL、(130.35±34.98)U/ mL，CTC-s、miR-196a、TSGF在 FIGO分期 ≥ⅡB期、分化程度为低分化、浸润深度为 >1/2肌层、有淋巴结转移的宫颈癌病人中明显升高( P<0.05)； Spearman相关性分析可知， CTC-s、miR-196a、TSGF与 FIGO分期、分化程度、浸润深度、淋巴结转移密切相关。 Kaplan-Meier生存曲线显示高水平的 CTC-s、miR-196a、SCC-Ag病人中位生存期明显缩短。 Cox回归分析结果显示 FIGO分期、分化程度、淋巴结转移以及 CTC-s、miR-196a、TSGF阳性表达是宫颈癌病人预后不良的独立危险因素( P<0.05)。结论宫颈癌病人 CTC-s、miR-196a、TSGF水平明显升高，且与病人临床病理特征和预后密切相关，可作为宫颈癌早期诊断和预后评估的有效指标。 |
| 英文摘要: |
| Objective To analyze the expression of circulating tumor cells (CTC-s), micro RNA 196a (miR-196a) and tumor-specificgrowth factor (TSGF) in patients with cervical cancer, and to explore their relationship with clinicopathological features and prognosis.Methods Using retrospective method, 116 cases of cervical cancer patients admitted to Shunyi District Hospital, Beijing TraditionalChinese Medicine Hospital from January 2016 to March 2017 were collected as cancer group, and 100 healthy women from physical examination center were collected as control group. CTC-s, miR-196a and TSGF levels in the two groups were detected, and the relationship between CTC-s, miR-196a and TSGF levels and clinicopathological features and prognosis were analyzed.Results The levels of CTC-s (5.92±1.32) n/mL, miR-196a (5.82±1.44), TSGF (109.65±27.68) U/mL in cancer group were significantly higher than those in control group CTC-s (0.55±0.14) n /mL, miR-196a (1.05±0.23), TSGF (30.54±8.11) U/mL, the differences were statistically significant (P<0.05). Ctc-s in patients with Federation International of Gynecology and Obstetrics stage ≥ⅡB, low differentiation, invasion depth >1/2 muscle layer and lymph node metastasis were (6.83±1.49) n/mL, (6.88±1.60) n/mL, (6.97±1.50) U/mL, (7.06±1.54) U/mL , respectively, while miR-196a were (7.01±1.57), (6.82±1.48), (7.00±1.57), (7.11±1.61), respectively. TSGF were (125.48±30.02) U/mL, (128.03±33.02) U/mL, (127.87±34.01) U/mL, (130.35±34.98) U/mL, respectively. CTC-s, miR-196a and TSGF were significantly increased in patients with FIGO stage≥ⅡB, low differentiation, invasion depth > 1/2 muscle layer and lymph node metastasis (P < 0.05). Spearman correlation analysis showed that CTC-s, miR-196a and TSGF were closely correlated with FIGO stage, degree of differentiation, depth of invasion and lymph node metastasis. Kaplan-meier survival curve showed that the median survival of patients with high levels of CTC-s, miR-196a, and TSGF was significantly shortened. Cox regression analysis showed that FIGO stage, degree of differentiation, lymph node metastasis and positive expression of CTC-s, miR-196a and TSGF were independent risk factors for poor prognosis of cervical cancer patients (P<0.05).Conclusions CTC-s, miR-196a and TSGF levels are significantly increased in cervical cancer patients, and are closely related to clinicopathological features and prognosis of the patients, which can be used as effective indicators for |
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