文章摘要
崔明新,刘晓刚,程大铭,等.血清微 RNA-429、肿瘤坏死因子受体相关因子 6与肝癌肝动脉化疗栓塞术灵敏度相关性及槐耳颗粒干预作用研究[J].安徽医药,2023,27(6):1144-1149.
血清微 RNA-429、肿瘤坏死因子受体相关因子 6与肝癌肝动脉化疗栓塞术灵敏度相关性及槐耳颗粒干预作用研究
Study on the correlation between serum miR-429, TRAF6 and TACE sensitivity of liver cancer and the intervention effect of Huaier granules
  
DOI:10.3969/j.issn.10096469.2023.06.019
中文关键词: 肝肿瘤  化学栓塞,治疗性  肝动脉  微 RNA-429  肿瘤坏死因子受体相关因子 6  灵敏度  槐耳颗粒
英文关键词: Liver neoplasms  Chemoembolization, therapeutic  Hepatic artery  Micro RNA-429  Tumor necrosis factor receptor-associated factor 6  Sensitivity  Huaier granules
基金项目:2021年度河北省中医药科研计划项目( 2021413)
作者单位E-mail
崔明新 唐山市工人医院肝胆外二科河北唐山 063000  
刘晓刚 唐山市工人医院肝胆外二科河北唐山 063000 deyleesh@21cn.com 
程大铭 唐山市工人医院肝胆外二科河北唐山 063000  
于敬坤 唐山市工人医院肝胆外二科河北唐山 063000  
曲凤智 唐山市工人医院肝胆外二科河北唐山 063000  
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中文摘要:
      目的探讨血清微 RNA-429(miR-429)、肿瘤坏死因子受体相关因子 6(TRAF6)与肝癌肝动脉化疗栓塞术(TACE)灵敏度相关性及槐耳颗粒干预作用。方法选取 2016年 1月至 2021年 1月唐山市工人医院收治的 80例肝癌病人,采用电脑随机数字表法按照随机、平行、对照原则分为对照组和观察组,各 40例。两组均给予 TACE治疗,对照组术后 1d起口服甲苯磺酸索拉非尼片,观察组在对照组基础上,于术前 1个月及术后 3d开始口服槐耳颗粒,术后 3个月评估疗效,比较两组治疗前、术后 1个月、术后 3个月血清 miR-429、TRAF6蛋白表达,应用 Spearman分析治疗前后血清 miR-429、TRAF6蛋白变化与灵敏度关系,并比较不同灵敏度病人治疗前血清 miR-429、TRAF6蛋白变化,采用受试者操作特征( ROC)曲线及曲线下面积( AUC)分析血清 miR-429、TRAF6蛋白治疗前后变化预测治疗灵敏度的价值, Pearson分析血清 miR-429与 TRAF6蛋白关系。结果观察组总有效率为 95.00%,高于对照组 80.00%,差异有统计学意义( P<0.05);观察组术后 1个月、术后 3个月血清 miR-429(0.42±0.11、0.51±0.13)高于对照组( 0.33±0.09、0.34±0.10)、 TRAF6蛋白( 2.49±0.65、2.02±0.57)低于对照组( 3.30±0.76、3.18±0.69)(P<0.05);观察组血清 miR-429、TRAF6蛋白术后 1个月与治疗前差值、术后 3个月与治疗前差值大于对照组( P<0.05);血清 miR-429、 TRAF6蛋白术后 1个月与治疗前差值、术后 3个月与治疗前差值和灵敏度呈正相关( P<0.05);血清 miR-429、TRAF6蛋白术后 1个月与治疗前差值、术后 3个月与治疗前差值:敏感 >一般 >较差( P<0.05);血清 miR-429、TRAF6蛋白术后 1个月与治疗前差值预测敏感的 AUC分别为 0.78、0.74;治疗前血清 miR-429与 TRAF6蛋白呈负相关( P<0.05)。结论血清 miR-429、TRAF6与肝癌 TACE灵敏度相关,槐耳颗粒可提高 miR-429表达,降低 TRAF6蛋白,增强肝癌 TACE灵敏度,提高疗效。
英文摘要:
      Objective To investigate the correlation between serum microRNA-429 (miR-429), tumor necrosis factor receptor-related factor 6 (TRAF6) and hepatocarcinoma hepatic artery chemoembolization (TACE) sensitivity and the intervention effect of Huaier granules.Methods A total of 80 patients with liver cancer who were admitted to Tangshan Workers′ Hospital from January 2016 toJanuary 2021 were selected and divided into control group and observation group according to the principles of randomization, parallelism and control by computer random number table method, with 40 cases in each group. Both groups were given TACE treatment. Thecontrol group was given sorafenib tosylate tablets orally 1 day after operation. On the basis of the control group, the observation groupwas given Huaier granules orally 1 month before operation and 3 days after operation. The curative effect was evaluated after 3 months,and the serum miR-429 and TRAF6 protein expressions were compared between the two groups before treatment, 1 month and 3months after surgery. Spearman was used to analyze the relationship between serum miR-429 and TRAF6 protein changes and sensitivity , and the changes of serum miR-429 and TRAF6 proteins before treatment in patients with different sensitivities were compared. Receiver operating characteristic curve (ROC) and area under ROC (AUC) were used to analyze the changes of serum miR-429 and TRAF6 proteins before and after treatment to predict treatment sensitivity. The correlation between serum miR-429 and TRAF6 protein was analyzed by Pearson analysis. Results The total effective rate in the observation group was 95.00%, which was higher than80.00% in the control group, and the difference was statistically significant (P<0.05), Serum miR-429 in the observation group at 1 and 3 months after surgery (0.42±0.11, 0.51±0.13) was higher than that in the control group (0.33±0.09, 0.34±0.10), while TRAF6 protein(2.49±0.65, 2.02±0.57) was lower than that in the control group (3.30±0.76, 3.18±0.69) (P<0.05); the difference in serum miR-429 and TRAF6 protein levels between the observation group and the control group at 1 month after surgery and before treatment, and at 3months after surgery and before treatment, was greater than that of the control group (P<0.05); the difference in serum miR-429 and TRAF6 protein levels between 1 month after surgery and before treatment, and between 3 months after surgery and before treatmentwere positively correlated with sensitivity (P<0.05); serum miR-429 and TRAF6 proteins at 1 month after surgery compared to beforetreatment, and 3 months after surgery compared to before treatment: sensitive>general>poor (P<0.05); the sensitive AUC for predicting the difference between serum miR-429 and TRAF6 proteins at 1 month after surgery and before treatment were 0.78 and 0.74, respectively; serum miR-429 before treatment was negatively correlated with TRAF6 protein (P<0.05). Conclusion Serum miR-429 and TRAF6 are related to the TACE sensitivity of liver cancer. Huaier granule can increase the expression of miR-429, reduce the TRAF6 protein, enhance the TACE sensitivity of liver cancer, and improve the therapeutic effect.
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