| 尹倩倩,潘天荣,钟兴,等.腺垂体功能减退症 123例临床分析[J].安徽医药,2023,27(6):1207-1210. |
| 腺垂体功能减退症 123例临床分析 |
| Clinical analysis of 123 cases of hypopituitarism |
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| DOI：10.3969/j.issn.1009-6469.2023.06.034 |
| 中文关键词: 腺垂体功能减退症 靶腺轴功能减退 低钠血症 高脂血症 低血糖 贫血 垂体危象 激素替代 |
| 英文关键词: Hypopituitarism Hypofunction of the target gland axis Hyponatremia Hyperlipidemia Hypoglycemia Anemia Pituitary crisis Hormone replacement |
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| 中文摘要: |
| 目的提高对腺垂体功能减退症的认识。方法对安徽医科大学第二附属医院内分泌科 2015年 8月至 2020年 9月收治的 123例腺垂体功能减退症病人的资料进行回顾性分析。结果男 47例( 38.2%)女 76例( 61.8%)年龄范围 16~83岁。颅内占位或术后 49例( 39.9%)希恩综合征 39例( 31.7%)，空泡蝶鞍综合征 15例( 12.2%)，下丘脑 -垂体发育，不良 9例( 7.3%)因不明 11例( 8.9%)。以消化道，症状就诊 47例( 38.2%，为首要就诊症状)垂体危象23例(，18.7%)。性腺轴受损104例(86.7%，病，为最主要受损腺体)3个腺体(性腺轴、甲状腺轴、肾上腺轴)均受损 61例(，55.5%)。低钠血症 60例( 52.2%)，血脂异常 87例(75%)，低血糖 21例(18，.8%)，贫血 47例( 40.9%)。结论腺垂体功能减退症临床表现多样，应提高对该病的认识，避免误诊和漏诊，确诊后及时予以激素替代治疗。 |
| 英文摘要: |
| Objective To improve the understanding of hypopituitarism.Methods Data from 123 patients with hypopituitarism admitted to the Department of Endocrinology, the Second Affiliated Hospital of Anhui Medical University, from August 2015 to September 2020 were retrospectively analyzed.Results There were 47 cases (38.2%) of males and 76 cases (61.8%) of females, with an agerange of 16 to 83 years. There were 49 cases (39.9%) of intracranial or postoperative occupancy, 39 cases (31.7%) of Sheehan′s syndrome, 15 cases (12.2%) of vacuolant saddle syndrome, 9 cases (7.3%) of hypothalamus-pituitary dysplasia, and 11 cases (8.9%) of unknown etiology. There were 47 patients (38.2%, the primary presenting symptom) with gastrointestinal symptoms and 23 patients(18.7%) with pituitary crisis. The gonadal axis was damaged in 104 cases (86.7%, the most predominantly damaged gland), and all 3glands (gonadal axis, thyroid axis, and adrenal axis) were damaged in 61 cases (55.5%). Hyponatremia was observed in 60 cases(52.2%), dyslipidemia in 87 cases (75%), hypoglycemia in 21 cases (18.8%), and anemia in 47 cases (40.9%).Conclusion The clinical manifestations of hypopituitarism are diverse, awareness of the disease should be improved to avoid misdiagnosis and underdiagnosis, and hormone replacement therapy should be given promptly after diagnosis. |
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