| 马锦,毛晨梅.408例儿童药品不良反应报告分析[J].安徽医药,2017,21(6):1150-1153. |
| 408例儿童药品不良反应报告分析 |
| Analysis of 408 pediatric cases with adverse drug reaction |
| 投稿时间：2016-11-26 |
| DOI： |
| 中文关键词: 儿童 药品不良反应 统计分析 用药安全 |
| 英文关键词: Children Adverse drug reaction Analysis Medication safety |
| 基金项目: |
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| 中文摘要: |
| 目的 了解儿童药品不良反应(ADR)发生情况,探讨不良反应发生特点,促进临床合理用药。方法 对苏州大学附属儿童医院2013—2014年408例儿童用药不良反应报告进行统计分析。 结果 408例ADR中,严重不良反应11例,其中9例均通过静脉给药引起,另外1例是检查前水合氯醛灌肠镇静引起,1例是双氯芬酸栓肛塞退烧中发生。10岁以下儿童发生ADR较多,共390例(95.59%)；抗感染药物发生ADR最多,共226例(55.39%)；静脉途径最易引起ADR,共341例(83.58%)；ADR的临床表现以皮肤损害最为常见,共345例(84.56%)。 结论 应注意儿童用药ADR发生的相关因素,年龄、给药途径、不良反应史等,加强ADR监测,有效避免或减少ADR发生,保障儿童用药的合理安全。 |
| 英文摘要: |
| Objective To investigate the occurrences of adverse drug reaction (ADR) in Children′s Hospital of Soochow University,explore the characteristics of adverse events and to promote a rational clinical drug use.Methods 408 cases of adverse drug reactions in our hospital over 2013 and 2014 were collected and analyzed.Results There were 11 serious ADR in the 408 ADRs,9 of which were caused by injection,while 1 caused by sedation with enema with chloral hydrate and 1 caused by inserting with diclofenac bolt to antipyretic.There were more adverse drug reactions in the children under 10 years old (390/408,5.59%).The adverse drug reactions were mostly caused by anti-microbial agents (226/408,5.39%).The vein administration (341/408,3.58%) were the main cause of drug adverse reactions.The most common clinical manifestation of ADR (age,route of administration,allergic history) was the damage of skin and its appendages (345/408,4.56%).Conclusions The relative factors of ADR in the child should be noted and ADR monitoring should be strengthened to reduce or avoid the reappearance of ADR,by which the safe and rational drug usage are guaranteed. |
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