| 朱一麟,高雪梅,贺漪.黄芪对妊娠期糖尿病患者外周血中孕激素、基质金属蛋白酶10、瘦素受体表达的影响[J].安徽医药,2017,21(9):1716-1719. |
| 黄芪对妊娠期糖尿病患者外周血中孕激素、基质金属蛋白酶10、瘦素受体表达的影响 |
| Effects of astragalus on the expressions of progesterone,matrix metalloproteinases 10,and leptin receptor in the peripheral blood of patients with gestational diabetes |
| 投稿时间：2016-08-29 |
| DOI： |
| 中文关键词: 妊娠期糖尿病 黄芪 孕激素 基质金属蛋白酶10 瘦素 瘦素受体 |
| 英文关键词: Gestational diabetes mellitus Astragalus Progesterone Matrix metalloproteinases 10 Leptin Leptin receptor |
| 基金项目:2010年武汉市卫生局临床医学科研项目(10C01) |
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| 中文摘要: |
| 目的 探讨黄芪对妊娠期糖尿病(GDM)患者外周血中孕激素、基质金属蛋白酶10(ADAM10)、瘦素(LEP)、瘦素受体(SLR)表达的影响。方法 选择60例GDM患者为GDM组,另选择60例健康产妇作为对照组。将60例GDM患者按照随机数字表法随机分为I组和Ⅱ组,每组各30例。I 组给予胰岛素联合黄芪治疗,Ⅱ组给予胰岛素治疗。检测脂联素(APN)、孕激素、ADAM10、LEP、SLR、空腹血糖(FBG)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)等指标。结果 GDM组血清孕激素、LEP水平明显高于对照组,差异有统计学意义(P<0.05)。GDM组血清ADAM10、SLR水平明显低于对照组,差异有统计学意义(P<0.05)。GDM孕妇孕激素、ADAM10、LEP、SLR水平的相关性显示,GDM孕妇孕激素与LEP呈正相关(rs=0.543,P＜0.001),GDM孕妇孕激素与ADAM10、SLR均呈负相关(rs =-0.516,P＜0.001；rs=-0.582,P＜0.001)。治疗后,I组、Ⅱ组孕激素、LEP水平均较治疗前下降,且I组下降幅度大于Ⅱ组,差异有统计学意义(P<0.05)。治疗后,I组、Ⅱ组ADAM10、SLR水平均较治疗前升高,且I组升高幅度大于Ⅱ组,差异有统计学意义(P<0.05)。I组FINS、HOMA-IR低于Ⅱ组,差异有统计学意义(P<0.05)。I组APN高于Ⅱ组,差异有统计学意义(P<0.05)。两组FBG比较差异无统计学意义(P＞0.05)。结论 与对照组比较,GDM孕妇外周血中孕激素、LEP升高,ADAM10、SLR下降。孕激素可通过对ADAM10在GDM中的表达进行调控,从而调控LEP和SLR,在GDM发病过程中发挥作用。黄芪可通过抑制孕激素的分泌,进而调控并升高ADAM10的水平,并进一步对LEP、SLR的分泌进行调控,最终达到改善GDM病情的作用。 |
| 英文摘要: |
| Objective To study the effects of Astragalus on the expressions of progesterone,matrix metalloproteinases 10,and leptin receptor in the peripheral blood of patients with gestational diabetes mellitus (GDM).Methods Sixty patients with GDM were selected as research objects,and 60 cases of healthy women were selected as healthy controls.Sixty patients with GDM according to random number table method were randomly assigned into group Iand group Ⅱ with 30 cases in each group.Patients in group Iwere given insulin combined with astragalus membranaceus therapy while patients in group Ⅱwere given insulin therapy.Adiponectin (APN),progesterone,ADAM10,LEP,SLR,fasting blood glucose (FBG),fasting insulin (FINS),insulin resistance index (HOMA-IR) were tested in both groups.Results Serum progesterone,LEP levels in GDM group were obviously higher than those of the control group,and the differences were statistically significant (P<0.05).Serum levels of ADAM10,SLR in GDM group were obviously lower than those of the control group,and the differences were statistically significant (P<0.05).Correlation analysis results showed that progesterone level of GDM pregnant women was positively related with LEP (rs=0.543,P＜0.001),and negatively correlated with ADAM10,SLR (rs=-0.516,P＜0.001;rs=-0.582,P＜0.001).After treatment,in both groups progesterone and LEP levels were decreased,and group Ifell more than group Ⅱ with statistically significant differences (P<0.05).After treatment,in both groups ADAM10 and SLR levels were higher,and group Irose more than group Ⅱ with statistically significant differences (P<0.05).FINS,HOMA-IR in group Iwere lower than groupⅡ,and the differences were statistically significant (P<0.05).APN in group Iwas higher than group Ⅱ,and the difference was statistically significant (P<0.05).FBG was similar between the two groups with no statistical significance (P>0.05).Conclusions Compared with healthy pregnant women,progesterone,LEP in the peripheral blood of GDM pregnant women rise,and ADAM10,SLR are lower in GDM pregnant women.Progesterone can control ADAM10 expression in GDM patients and influence LEP and SLR levels,which plays a role in the pathogenesis of GDM.Astragalus membranaceus may inhibit the secretion of progesterone,regulate and increases the level of ADAM10,and further adjust the secretion of LEP,SLR,and eventually improve the GDM condition. |
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