| 贺峰,孙晓东.血清C-反应蛋白、降钙素原及乳酸在脑外伤患者术后颅内感染诊断意义研究[J].安徽医药,2017,21(11):2035. |
| 血清C-反应蛋白、降钙素原及乳酸在脑外伤患者术后颅内感染诊断意义研究 |
| Significance of serum CRP,PCT and lactic acid in the diagnosis of postoperative intracranial infection in patients with brain injury |
| 投稿时间：2016-12-14 |
| DOI： |
| 中文关键词: 颅内感染 C-反应蛋白 降钙素原 乳酸 |
| 英文关键词: Intracranial infection C reactive protein Procalcitonin Lactic acid |
| 基金项目: |
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| 摘要点击次数: 2004 |
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| 中文摘要: |
| 目的 探讨血清C-反应蛋白(CPR)、降钙素原(PCT)及乳酸在脑外伤患者术后颅内感染的诊断价值。方法 选取87例神经外科脑外伤术后患者,按照颅内感染标准,将患者分为感染组(n=47)和非感染组(n=40),感染组患者根据预后又分为治愈组、好转组和加重、无效组。检测血清CPR、PCT及乳酸水平的变化情况,比较各指标受试者工作特征(ROC)曲线下面积。结果 感染组患者血清CPR、PCT及乳酸水平明显增加(P<0.05)；与治愈组和好转组相比,加重、无效组CPR、PCT明显升高(P<0.05),治愈组血清CPR及PCT水平明显低于好转组(P<0.05)；血清CPR、PCT及乳酸ROC曲线下面积分别为0.876,0.966,0.717(P<0.05),血清PCT在8.10 μg·L-1时为最佳截断点,诊断的敏感度为89.4%,特异度为92.5%,优于其他两项血清指标。结论 血清CPR、PCT及乳酸的检测,有望成为鉴别诊断颅内感染的新型标志物。 |
| 英文摘要: |
| Objective To explore the diagnostic value of Creactive protein(CRP),procalcitonin(PCT) and lactic acid for intracranial infection. Methods Eighty-seven patients were assigned into two groups:infection group(n=47) and non-infection group(n=40) according to intracranial infection criteria,the patients in the infection group were assigned into the cure group,the improved group and theaggravating and ineffective group according to the prognosis.Serum CRP,PCT and lactic acid were tested and compared.The diagnostic value was evaluated by means of the area under curve of race iver-operating-characteristic(ROC)curve. Results Compared with the control group,serum CRP,PCT and lactic acid were significantly increased in infection group(P<0.05).Compared with the aggravating group and ineffective group,serum CRP and PCT significantly reduced in the cure group and the improved group(P<0.05).Serum CRP and PCT in the cure group significantly reduced than that in the improved group(P<0.05).The area under curve of serum CRP,PCT and lactic acid were 0.876,0.966,0.717(P<0.05),respectively.The optimal cut-off point of serum calcitonin was 8.10 μg·L-1,the sensitivity of diagnosis was 89.4%,specificity was 92.5%,which was better than the other two serum markers. Conclusions The test of serum CRP,PCT and lactic acid is expected to be a novel biomarker for the diagnosis of intracranial infection. |
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