| 黄宇,贺王伟,黄峥嵘.佐匹克隆与盐酸曲唑酮治疗睡眠障碍的临床疗效观察[J].安徽医药,2018,22(6):1142-1144. |
| 佐匹克隆与盐酸曲唑酮治疗睡眠障碍的临床疗效观察 |
| A clinical comparative analysis of zopiclone and trazodone hydrochloride in the treatment of sleep disorders |
| 投稿时间：2017-10-12 |
| DOI： |
| 中文关键词: 睡眠障碍 佐匹克隆 曲唑酮 治疗结果 |
| 英文关键词: Sleep disorders Zopiclone Trazodone Treatment outcome |
| 基金项目:国家自然科学基金资助项目(81670224) |
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| 中文摘要: |
| 目的 观察佐匹克隆与盐酸曲唑酮治疗睡眠障碍的临床疗效和安全性。 方法 将100例睡眠障碍患者采用随机数字表的方法分为治疗组50例和对照组50例。治疗组给予佐匹克隆治疗,对照组给予盐酸曲唑酮治疗。两组均为睡前30 min给药,疗程4周。比较两组临床治疗效果。 结果 治疗后,两种药品在延长患者总睡眠时间方面差异无统计学意义[(0.9±0.3)h比(0.9±0.7) h,P＞0.05]。佐匹克隆治疗睡眠障碍的入睡时间评分低于盐酸曲唑酮[(0.5±0.2)分比(1.3±0.4)分,P＜0.05]。问卷自评量表(self-rating scale of sleep,SRSS)评分与本组治疗前比较明显降低(P＜0.05),但是治疗后两组组间比较差异无统计学意义(P＞0.05)。治疗组不良反应量表(TESS)低于对照组[(9.45±4.37)分比(12.56±4.62)分,P＜0.05]。 结论 佐匹克隆与盐酸曲唑酮在睡眠障碍的治疗效果上疗效一致。但佐匹克隆药物不良反应更低,容易被患者接受。 |
| 英文摘要: |
| Objective To observe clinical effect and safety of Zopiclone and Trazodone Hydrochloride in the treatment of sleep disorders. Methods A total of 100 patients with sleep disorders were randomly assigned into treatment group and control group,50 cases in each group.The treatment group received Zopiclone for treatment,and the control group received Trazodone Hydrochloride for treatment.The drugs were both given 30 min before bedtime for 4 weeks.The clinical effects of the 2 groups were compared.Results After treatment,there was no statistically significant difference between the 2 drugs in prolonging the total sleep duration of the patients [(0.9±0.3) hours vs (0.9±0.7) hours,P＞0.05].The sleeping time score of sleeping disorder treated with Zopiclone was lower than that of Trazodone Hydrochloride [(0.5±0.2) scores vs (1.3±0.4) scores, P＜0.05].The self-rating scale of sleep (SRSS) score was lower than that before treatment in the same group(P＜0.05),but there was no statistically significant between two groups after treatment.The treatment group had lower Treatment Emergent Symptom Scale than the control group [(9.45±4.37) scores vs (12.56±4.62) scores,P＜0.05]. Conclusions The curative effects of Zopiclone and Trazodone Hydrochloride in the treatment of sleep disorders are consistent.But the adverse reactions of Zopiclone are slighter and it is easily accepted by patients. |
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