| 赵开雷,夏宏林.胱抑素C和D-二聚体在诊断妊娠糖尿病早期肾损伤中的临床价值[J].安徽医药,2018,22(8):1477-1480. |
| 胱抑素C和D-二聚体在诊断妊娠糖尿病早期肾损伤中的临床价值 |
| The clinical value of cystatin Cand D-dimer in diagnosis of early renal damage of gestational diabetes |
| 投稿时间：2017-03-24 |
| DOI： |
| 中文关键词: 妊娠糖尿病 早期肾损伤 D-二聚体 胱抑素C GFR |
| 英文关键词: Gestational diabetes Early renal damage D-dimer The cystatin C GFR |
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| 摘要点击次数: 1937 |
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| 中文摘要: |
| 目的 研究胱抑素C(Cys-C) 、D-二聚体(D-D)和肾小球滤过率(GFR)监测妊娠糖尿病(GDM)早期肾损伤的临床价值。方法 比较GDM患者中肾功能正常组(31例)、肾功能不全代偿组(63例)以及健康对照组(30例)Cys-C、D-D及GFR检测情况,研究Cys-C及D-D与GFR相关性,运用SPSS 13.0 软件分析获得Cys-C、D-D和GFR的受试者工作特征曲线(ROC),并对GDM患者早期肾损伤诊断进行方法学评价。结果(1)GDM肾功能不全代偿组Cys-C、D-D和GFR与健康对照组、GDM肾功能正常组比较均差异有统计学意义(P<0.05)；GDM肾功能正常组及健康对照组D-D、Cys-C和GFR比较均差异无统计学意义(P>0.05)。(2)相关性显示:GDM患者中血清Cys-C 与GFR(r=-0.866,P<0.05)呈负相关,D-D与GFR (r=-0.602,P<0.05)呈负相关,相关系数Cys-C 高于D-D；两组诊断异常率比较,Cys-C>D-D>GFR。(3)GDM患者Cys-C曲线形面积(AUC)大于D-D和GFR曲线形面积,差异有统计学意义(P<0.01),其中Cys-C和D-D符合率分别为86.4%和83.8%,约登指数分别为0.72和0.67。结论 Cys-C 及D-D在GDM肾功能监测方面有较高的灵敏度,对GDM患者早期肾损伤诊断有重要的临床应用价值。 |
| 英文摘要: |
| Objective To study the clinical application value of cystatin C (Cys-C), D-dimer (D-D) and glomerular filtration rate (GFR)in gestational diabetes mellitus patients with early renal damage renal function monitoring. Methods By comparing of normal renal function (31 cases) in patients with gestational diabetes mellitus(31 cases), renal insufficiency compensatory patients (63 cases), normal renal function group (30 cases) cystatin Cand D-dimer inspection situation, cystatin C, D-dimer correlation with GFR were analyzed. Using SPSS13.0 software, we analysis for cystatin C, D-dimer and the receiver-operating characteristic (ROC) of GFR and evaluate early renal damage in patients with gestational diabetes mellitus diagnosis methodology. Results(1)The difference of cystatin C, D-dimer and GFR between gestational diabetes renal insufficiency compensatory group, healthy controls and gestational diabetes normal renal function group were statistically significant (P<0.05). There was no statistical difference of cystatin C, D-dimerand GFR between normal renal function group and health control group had in (P>0.05). (2) Correlation shows:The correlation of serum cystatin Cand GFR between GDM patients (r=0.866, P<0.05) was negative, Correlation coefficient of cystatin Chigher than that of D-dimer. Four groups of diagnosis of abnormal rate comparison showed cystatin C>D-dimer>GFR.(3)Evalution of methodology:The Cys - C curved area in patients with gestational diabetes mellitus was greater than the D-dimer and GFR. The difference was statistically significant (P<0.01). The Cys-C coincidence rate were 86.4% and 83.8%, Youden index were 0.72 and 0.67 respectively. Conclusion Cys-C and D-dimer have higher sensitivity in gestational diabetes renal function monitoring. Early renal damage in patients with gestational diabetes diagnosis has important clinical value. |
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