| 张斌,姚影珍,张立兴,等.生骨胶囊联合低分子肝素治疗脊柱术后下肢深静脉血栓48例疗效观察[J].安徽医药,2019,23(5):998-1001. |
| 生骨胶囊联合低分子肝素治疗脊柱术后下肢深静脉血栓48例疗效观察 |
| Effects and safety of Shenggu capsule combined with low molecular heparin on the postoperative lower limb deep vein thrombosis after spinal surgery |
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| DOI：10.3969/j.issn.1009-6469.2019.05.044 |
| 中文关键词: 静脉血栓形成 下肢 矫形外科手术/副作用 脊柱 肝素,低分子量 治疗结果 生骨胶囊 |
| 英文关键词: Venous thrombosis Lower extremity Orthopedic procedures/adverse effects Spine Heparin,low-molecular-weight Treatment outcome Shenggu capsule |
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| 中文摘要: |
| 目的 观察生骨胶囊联合低分子肝素对脊柱术后下肢深静脉血栓(DVT)疗效及安全性的影响。方法 选择2015年12月至2016年11月于石家庄市第一医院行脊柱外科手术病人96例作为研究对象,采用随机数字表法将其分为观察组(48例)与对照组(48例)。对照组给予低分子肝素治疗,每天4 100 IU,皮下注射。观察组则在对照组用药治疗基础上加以口服生骨胶囊,5粒/次,3次/天。观察两组临床疗效、DVT发生率、不良反应发生情况以及治疗前后血液流变学、腘静脉内径(POPV)、股浅静脉内径(FSV)等变化情况。结果 观察组总有效95.83%高于对照组77.08%,DVT发生率4.17%低于对照组20.83%,差异有统计学意义(P＜0.05)。治疗后观察组PT、FIB、D-D指标水平较高于治疗前,差异有统计学意义(P＜0.05)。治疗后观察组FIB(4.02±0.46) g/L、D-D(385.24±26.41) μg/L指标水平较低于对照组FIB(4.63±0.51) g/L、D-D(511.61±22.29) μg/L,差异有统计学意义(P＜0.05)。治疗前两组FSV与POPV检测结果对比,差异无统计学意义(P＞0.05);治疗后观察组FSV与POPV较治疗前对比,差异无统计学意义(P＞0.05);治疗后对照组FSV(7.03±1.79) mm与POPV(7.96±1.63) mm显著低于观察组FSV(8.52±1.23) mm与POPV(9.52±1.23)mm,差异有统计学意义(P＜0.05)。治疗期间两组用药不良反应发生率差异无统计学意义(P＞0.05)。结论 生骨胶囊与低分子肝素联合治疗有助于降低脊柱术后下肢深静脉血栓发生率,加速病人术后康复,改善血液流变学,安全性良好,临床普及价值高。 |
| 英文摘要: |
| Objective To observe the effects and safety of Shenggu capsule combined with low molecular heparin after spinal surgery on the postoperative lower limb deep vein thrombosis (DVT).Methods The clinical data of 96 patients who had received spinal surgery in the First Hospital of Shijiazhuang between December 2015 and November 2016 were selected as the research objects.According to the random table method,these patients were divided into an observation group (n＝48) and a control group (n＝48).The control group was given low molecular heparin for treatment,whereas the observation group was treated with Shenggu capsule plus low molecular heparin.The clinical effects,incidence of DVT,adverse reactions and the changes of hemorheology,diameter of the popliteal vein (POPV) and femoral superficial vein diameter (FSV) were compared between the two groups.Results The total effective rate in the observation group 95.83% was shown to be higher than that of the control group 77.08%,and the incidence of DVT 4.17% was lower than that of the control group 20.83%,where the difference was statistically significant (P＜0.05).The levels of PT,FIB and D-D in the two groups were significantly higher than those before treatment (P＜0.05).The FIB (4.02±0.46) g/L and D-D (385.24±26.41) μg/L indexes of the observation group were lower than those of the control group FIB (4.63±0.51) g/L and D-D (511.61±22.29) μg/L,the difference was statistically significant (P＜0.05).Before treatment,there was no statistically significant difference registered in the FSV and POPV between the two groups (P＞0.05),after treatment,however,the FSV(8.03±1.79)mm and POPV(7.96±1.63)mm results in the control group were shown to be lower than the observation group FSV(8.52±1.25) mm and POPV(9.52±1.23)mm,and the difference was statistically significant (P＜0.05).During the treatment,there was no statistically significant difference shown in the incidence of adverse reactions caused by medication (P＞0.05).Conclusion For patients after spinal surgery,Shenggu capsule combined with low molecular heparin is with high safety,and can help to reduce the incidence of postoperative lower limb deep vein thrombosis,improve the postoperative rehabilitation of the patients and the blood rheology;therefore,it is of significant value in clinical application. |
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