| 夏庆润,刘超,杨魁,等.小剂量丙戊酸镁对精神分裂症阳性症状病人认知功能及血清脑源性、胶质源性神经营养因子水平的影响[J].安徽医药,2019,23(10):2082-2086. |
| 小剂量丙戊酸镁对精神分裂症阳性症状病人认知功能及血清脑源性、胶质源性神经营养因子水平的影响 |
| Effects of low doses of magnesium valproate on cognitive function and serum levels of BDNF and GDNF in schizophrenia patients with positive symptoms |
| |
| DOI：10.3969/j.issn.1009?6469.2019.10.045 |
| 中文关键词: 精神分裂症 氯氮平 丙戊酸镁 脑源性神经营养因子 胶质细胞源性神经营养因子 认知障碍 治疗结果 |
| 英文关键词: |
| 基金项目: |
|
| 摘要点击次数: 1861 |
| 全文下载次数: 669 |
| 中文摘要: |
| 目的探讨小剂量丙戊酸镁增效治疗对精神分裂症( SCH)阳性症状病人认知功能及血清脑源性神经营养因子( BDNF)和胶质源性神经营养因子( GDNF)水平的影响。方法选取沈阳市精神卫生中心自 2014年 3月至 2016年 3月收治的 90例 SCH病人作为研究对象，采用随机数字表法分为两组:对照组( n＝45)应用氯氮平与安慰剂治疗，观察组( n＝45)应用氯氮平与小剂量丙戊酸镁治疗，两组疗程均为 12周。比较两组临床疗效，治疗前及治疗后评价阳性和阴性症状量表( PANSS)评分、改良版威期康星卡片分类测验( M?WCST)、连线测验( TMT)、词汇流畅性测验( VFT)评分；治疗前后测定血清 BDNF和 GDNF水平。结果治疗后观察组总有效率为 95.56%显著高于对照组的 77.78%(Z＝7.867，χ2＝6.154，P＜0.05)；治疗后，观察组的 PANSS、TMT、M?WCST中错误数、持续错误数与非持续错误数均显著低于对照组( t＝6.594，9.494，4.980，6.838；P＜0.05)M?WCST中正确数、正确分类数均显著高于对照组(t＝7.985，12.836；P＜0.05)；治疗后，观察组的血清 BDNF为(11.78±3.01)μg/L、，GDNF水平为( 553.71±102.24)pg/mL，两项指标均显著高于对照组 BDNF(10.04±2.43)μg/L、GDNF(466.69±75.98)pg/mL(t＝ 3.017，4.583；P＜0.05)；两组总不良反应率比较差异无统计学意义( χ2＝0.756，P＞0.05)。结论小剂量丙戊酸镁辅助治疗 SCH安全有效，对认知功能损害具有部分改善作用，其机制可能与上调血清 BDNF、GDNF表达有关。 |
| 英文摘要: |
| Objective To explore the effects of augmentative treatment of low doses of magnesium valproate on cognitive functionand serum levels of brain derived neurotrophic factor(BDNF)and glial cell line?derived neurotrophic factor(GDNF)in schizo? phrenia(SCH)patients with positive symptoms.Methods Ninety cases of SCH patients admitted to Shenyang Mental Health Cen?ter from March 2014 to March 2016 were selected as subjects.They were randomly assigned into two groups:the observation group(n＝45)was treated with clozapine and low doses of magnesium valproate，while the control group(n＝45)was treated with clo? zapine and placebo.The course of treatment was 12 weeks in both groups.The clinical efficacy between the two groups were com?pared，the Positive and Negative Symptom Scale(PANSS)，Modified Wisconsin Card Sorting Test(M?WCST)，Trail Making Test(TMT)，Verbal Fluency Test(VFT)scores were evaluated before and after treatment，and the serum BDNF and GDNF levels were detected before and after treatment.Results After treatment，the total effective rate of the observation group was 95.56%，which was significantly higher than 77.78% of the control group(Z＝7.867，χ2＝6.154，P＜0.05)； After treatment，the errors，preservativeerrors，non?preservative errors of PANSS，TMT and M?WCST，in the observation group were significantly lower than those in the con? trol group(t＝6.594，9.494，4.980，6.838；P＜0.05).The correct number and correct number of classifications of M?WCST scores of the observation group were significantly higher than those of the control group(t＝7.985，12.836；P＜0.05).After treatment，the se? rum BDNF level of the observation group was(11.78±3.01)μg/L，and the serum GDNF level was(553.71±102.24)pg/mL.Both in? dexes were significantly higher than those of the control group［serum BDNF level:(10.04±2.43)μg/L；serum GDNF level:(466.69± |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
