| 王干一,夏旭东,彭亚丽,等.儿童药物不良反应 1 103例分析[J].安徽医药,2020,24(3):627-630. |
| 儿童药物不良反应 1 103例分析 |
| Analysis of adverse drug reactions in 1 103 children |
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| DOI：10.3969/j.issn.1009?6469.2020.03.053 |
| 中文关键词: 药物毒性 药物警戒性 药物副反应报告系统 儿童 |
| 英文关键词: Drug toxicity Pharmacovigilance Adverse drug reaction reporting systems Child |
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| 中文摘要: |
| 目的分析 1 103例儿童用药不良反应发生的特征，为临床合理的规避儿童用药风险提供理论依据和参考。方法采用回顾性分析方法，对 2018年度河南省药品不良反应监测中心所提供的 1 103例儿童不良反应数据进行统计分析。结果在 1 103份报告中，男性 698例，占总数的 63.30%；男女比例为 1.72∶1。1岁以下病儿发生不良反应例数最多，为 392例，占总数的 35.54%。药物不良反应涉及药品以抗微生物药为主，出现 315例次，占比 28.56%。涉及给药剂型最多的为注射剂类，出现 741例次，占比 67.18%。给药途径出现例次最多的是静脉滴注，出现 734例次，占比 66.55%。皮肤及其附件损害是主要累及的系统/器官，频次为 613例，占比 40.79%。报告类型一般的病儿 994例，占比 90.1%。对病儿进行对症治疗后，痊愈和好转病儿 1 089例，占比 98.73%。结论 1 103例儿童药物不良反应中， 1岁以下儿童占比较高，且注射剂类药品占比高，提示医务人员在临床工作中要规范用药、合理用药，对于低龄儿童用药更需慎重。 |
| 英文摘要: |
| Objective To analysis the characteristics and regularity of pediatric adverse drug reactions(ADR)，in order to provide theoretical basis and reference for children clinical medication.Methods In retrospective study，1 103 pediatric ADR cases col? lected from ADR Center in 2018 were analyzed statistically.Results Among 1 103 pediatric ADR cases，698 cases were male(63.30%)， the ratio of men to women was 1.72 to 1.The incidence of ADR in patient age under one year old was the highest(35.54%)，about 392 cases.ADR were mainly related to antimicrobial drugs，which occurred 315 times，accounting for 28.56%.In? jections were the most frequently used forms of drug delivery，with 741 cases(67.18%).The most frequent route of administration was intravenous drip，734 times，accounting for 66.55%.The lesion of skin and its appendages were the main system/organ involved， the frequency was 613 cases，accounting for 40.79%.994 patients(90.1%)reported general types.After symptomatic treatment， 1 089 patients recovered and improved，accounting for 98.73%.Conclusion Among the ADR of 1 103 children，the proportion of children under one year old is higher，and injections accounted for a higher proportion，which suggested that medical staff should standardize and rational drug use in clinical work，and be more cautious in the use of drugs for young children. |
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