| 潘颖,戴力.冷诱导 RNA结合蛋白与冠心病病人冠状动脉狭窄程度的相关性[J].安徽医药,2021,25(2):308-312. |
| 冷诱导 RNA结合蛋白与冠心病病人冠状动脉狭窄程度的相关性 |
| Correlation between cold-inducible RNA-binding protein and coronary artery stenosis in patients with coronary heart disease |
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| DOI：10.3969/j.issn.1009-6469.2021.02.024. |
| 中文关键词: 冠心病 冠状动脉狭窄 冷诱导 RNA结合蛋白(CIRP) 炎性因子 |
| 英文关键词: Coronary disease Coronary stenosis Cold-inducible RNA-binding protein (CIRP) Inflammatory factor |
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| 中文摘要: |
| 目的探讨血清中冷诱导 RNA结合蛋白( CIRP)水平与冠心病病人冠状动脉狭窄程度的相关性。方法选取 2018年 3月至 2019年 12月灵宝市第一人民医院收住的冠心病病人 196例，根据 Gensini评分分为 3组，即轻度组(< 18分)、中度组( 18~ 41分)、重度组(≥ 41分)。入院后收集基线临床资料，采用酶联免疫吸附试验测定血清中 CIRP与炎性因子的水平，比较 3组间各指标的差异；采用 Pearson法分析 CIRP与炎性因子的相关性；有序多分类 logistic回归模型分析冠脉狭窄程度的独立危险因素； ROC工作曲线分析 CIRP水平对重度冠脉狭窄( Gensini评分 ≥ 41分)的诊断价值。结果轻、中、重度组总胆固醇( TC)［(3.32±0.67)、(4.40±1.02)、(4.81±0.99)mmol/L］、三酰甘油(TG)［(1.53±0.53)、(1.71±0.66)、(1.99±0.67)mmol/L］、低密度脂蛋白胆固醇( LDL-C)［( 2.45±0.76)、(2.82±1.04)、(3.14±1.31)mmol/L］、高密度脂蛋白胆固醇( HDL-C)［( 1.18±0.23)、(1.07±0.30)、(0.89±0.21)mmol/L］、超敏 C反应蛋白( hs-CRP)［( 20.67±3.99)、(34.39±5.20)、(42.39±6.12)mg/L］、左心室舒张末期内径(LVEDd)［( 48.04±5.33)、(51.91±6.24)、(53.59±7.12)mm］、左心室射血分数( LVEF)［( 60.27±8.70)%、(56.18±8.93)%、(54.30± 8.20)%］比较，差异有统计学意义( P < 0.05)。与轻度组和中度组相比较，重度组病人血清中 CIRP［( 128.77±16.80)ng/L比(72.91±10.43)、(95.06±12.39)ng/L］、白细胞介素 -1β(IL-1β)［(14.03±2.05)ng/L比( 4.14±1.08)、(8.80±1.95)ng/L］、白细胞介素 -6(IL-6)［( 29.48±4.51)ng/L比( 17.85±3.39)、(20.52±4.66)ng/L］、肿瘤坏死因子 -α(TNF-α)［( 49.62±6.99)ng/L比( 26.17±4.65)、(35.44±5.83)ng/L］含量升高( P < 0.05)。 CIRP水平与 IL-1β(r = 0.785，P < 0.001)、 IL-6(r=0.736，P < 0.001)、 TNF-α(r = 0.739， P < 0.001)含量呈正相关。 ROC曲线下面积为 0.972(95%CI:0.954～0.991，P < 0.001)以血清 CIRP水平 > 110.70 ng/L作为截断值时，对重度冠脉狭窄的诊断敏感度为 0.854，特异度为 0.968。结论血清中 CIRP水，平与炎性因子含量呈正相关，与冠状动脉狭窄程度密切相关，有较好的预测与诊断价值。 |
| 英文摘要: |
| Objective To analyze the relationship between cold-inducible RNA-binding protein and coronary artery stenosis in patients with coronary heart disease.Methods A total of 196 patients with coronary heart disease admitted to Lingbao First People'sHospital from March 2018 to December 2019 were selected as the research objects, and they were assigned into 3 groups according tothe Gensini score, namely mild group ( < 18 points), moderate group (18 points ≤ X < 41 points), and severe group (≥ 41 points). Baseline clinical data were collected after admission, and the levels of CIRP and inflammatory factors in serum were measured using enzyme-linked immunosorbent assay, and the differences in each index among the three groups were compared. Correlation between CIRPand inflammatory factors was analyzed using Pearson method. Independent risk factors for coronary stenosis were analyzed using an ordered multi-class logistic regression model. ROC working curve was used to analyze the diagnostic value of CIRP level in severe coronary stenosis (Gensini score≥41 points).Results There were significant differences in TC [(3.32±0.67),(4.40±1.02), (4.81±0.99) mmol/L], TG [(1.53±0.53), (1.71±0.66), (1.99±0.67) mmol/L], LDL-C [(2.45±0.76), (2.82±1.04), (3.14±1.31) mmol/L], HDL-C [(1.18±0.23), (1.07±0.30),(0.89±0.21) mmol/L],hs-CRP [(20.67±3.99),(34.39±5.20),(42.39±6.12) mg/L], LVEDd [(48.04±5.33),(51.91±6.24),(53.59±7.12) mm], and LVEF [(60.27±8.70)%, (56.18±8.93)%,(54.30±8.20)%] among the three groups (P < 0.05). Compared with the mild group and the moderate group, the serum levels of CIRP [(128.77±16.80) ng/L vs. (72.91±10.43),(95.06±12.39) ng/L],IL-1β [(14.03± 2.05) ng/L vs. (4.14±1.08),(8.80±1.95) ng/L],IL-6 [(29.48±4.51)ng/L vs. (17.85±3.39),(20.52±4.66) ng/L]6,and TNF-α [(49.62±6.99) ng/ L vs. (26.17±4.65),(35.44±5.83) ng/L] increased in patients with the severe group (P < 0.05). CIRP levels were positively correlated with IL-1β (r = 0.785,P < 0.001),IL-6(r = 0.736,P < 0.001), and TNF-α(r = 0.739, P < 0.001) levels.The area under the ROC curve was 0.972 (95% CI = 0.954～0.991,P < 0.001).When the serum CIRP level≥110.70 ng/L was used as the cutoff value,the diagnosticsensitivity for severe coronary stenosis was 0.854 and the specificity was 0.968.Conclusion The serum level of CIRP is positively correlated with the content of inflammatory factors, and is closely related to the degree of coronary artery stenosis,which has a good prediction and diagnostic value. |
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