| 魏磊,刘翠华,刘平,等.扶正化瘀法治疗儿童狼疮性肾炎 24例[J].安徽医药,2021,25(5):1048-1052. |
| 扶正化瘀法治疗儿童狼疮性肾炎 24例 |
| Constitution consolidation and resolving blood stasis method for treating lupus nephritis in children: 24 cases |
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| DOI：10.3969/j.issn.1009-6469.2021.05.051 |
| 中文关键词: 狼疮肾炎 扶正化瘀法 儿童 回顾性分析 |
| 英文关键词: Lupus nephritis Constitution consolidation and resolving blood stasis method Children Retrospective analysis |
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| 中文摘要: |
| 目的回顾性分析扶正化瘀法治疗儿童狼疮性肾炎( LN)的疗效及安全性。方法选取 2010年 1月至 2018年 7月郑州大学附属儿童医院收治的 LN病儿 48例，依据治疗方式不同将其分为观察组及对照组，各 24例，对照组予以常规(降压、利尿、抗感染、抗凝等)结合醋酸泼尼松与环磷酰胺治疗，观察组在对照组基础上采用扶正化瘀方进行治疗。比较两组治疗有效率、治疗前后 24 h尿蛋白定量、肾功能［尿素氮( BUN)、肌酐( Scr)、活动性指数( AI)、慢性化指数( CI)］、免疫功能［C反应蛋白(CRP)、补体 C3、补体 C4］变化、不良反应发生率。结果观察组治疗有效率明显高于对照组( 91.67%比 66.67%，P<0.05)；观察组治疗 3个月［( 1.20±0.15)g/L比( 1.29±0.14)g/L］、 6个月［(0.09±0.02)g/L比( 0.15±0.04)g/L］24 h尿蛋白水平低于对照组，差异有统计学意义( P<0.05)；观察组治疗后 BUN［( 6.47±0.69)nmol/L比( 7.03±0.72)nmol/L］、 Scr［( 64.41±6.67)μmol/L比( 69.07±7.14)μmol/L］、 AI［( 2.79±0.29)分比( 3.47±0.38)分］、 CI［( 1.08±0.09)分比( 1.22±0.15)分］低于对照组( P<0.05)；观察组治疗后 CRP水平［( 5.42±0.54)mg/L比( 6.85±0.73)mg/L］低于对照组，而补体 C3［( 0.92±0.09)g/L比( 0.87±0.05)g/L］、补体 C4［( 0.25±0.04)g/L比( 0.19±0.02)g/L］水平较对照组高( P<0.05)；观察组与对照组不良反应发生率比较差异无统计学意义( 13.95%比10.00%，P>0.05)。结论扶正化瘀法治疗 LN儿童疗效较好，可明显改善病儿 24 h尿蛋白定量、肾功能、免疫功能，安全可靠，值得在临床推广实践。 |
| 英文摘要: |
| Objective To retrospectively analyze the curative effect and safety of constitution consolidation and resolving blood stasis method for treating lupus nephritis (LN) in children.Methods A retrospective analysis was carried out in 48 children with LN admitted to the Children′s Hospital Affiliated to Zhengzhou University from January 2010 to July 2018. The children were divided into observation group (n=24) and control group (n=24) according to different treatment methods. The response rate, changes in 24-hour urine protein quantification, renal function [blood urea nitrogen (BUN), creatinine (Scr), activity index (AI), chronic index (CI)] and immunefunction [C-reactive protein (CRP), complement C3, complement C4] before and after treatment, and the incidence of adverse reactionswere compared between the two groups.Results The response rate of the observation group was significantly higher than that of the control group (91.67% vs. 66.67%,P<0.05). Levels of urine protein in the observation group were lower than those in the control group at 3 months[ (1.20±0.15) g/L vs. (1.29±0.14) g/L] and 6 months[(0.09±0.02) g/L vs. (0.15±0.04) g/L] after treatment (P<0.05). After treatment, BUN [(6.47±0.69) nmol/L vs. (7.03±0.72) nmol/L], Scr [(64.41±6.67)μmol/L vs. (69.07±7.14)μmol/L], AI [(2.79±0.29) vs. (3.47± 0.38)] and CI [(1.08±0.09) vs. (1.22±0.15)] in the observation group were lower than those in the control group (P<0.05). The CRP level in the observation group was lower than that in the control group [(5.42±0.54) mg/L vs. (6.85±0.73) mg/L], while levels of complement C3 [(0.92±0.09) g/L vs. (0.87±0.05) g/L] and complement C4 [(0.25±0.04) g/L vs. (0.19±0.02) g/L] were higher than those in the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (13.95% vs. 10.00%,P >0.05).Conclusion The constitution consolidation and resolving blood stasis method is effective in the treatment of children with LN.It can significantly improve the 24-hour urine protein quantification, renal function and immune function of children. It is safe and reliable. |
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